Immunohistochemical detection of NO synthases after endothelial denudation.
نویسندگان
چکیده
منابع مشابه
Diverse Functions of Endothelial NO Synthases System: NO and EDH
Endothelium-dependent relaxations are predominantly regulated by nitric oxide (NO) in large conduit arteries and by endothelium-dependent hyperpolarization (EDH) in small resistance vessels. Although the nature of EDH factors varies depending on species and vascular beds, we have previously demonstrated that endothelial NO synthases (eNOS)-derived hydrogen peroxide (H2O2) is an EDH factor in an...
متن کاملInhibition of endothelial cell regrowth. Cessation of aortic endothelial cell replication after balloon catheter denudation.
Aortas of male rabbits (2.0 to 2.5 kg body weight) were denuded of endothelium with a 4F balloon catheter and killed 7, 14, 60, 90, and 180 days later. Aortic endothelial cells regrowth was determined using Evans blue dye and scanning electron microscopy. Early endothelial outgrowth was rapid, but by 14 days the regrowth slowed markedly so that no further increase of endothelial outgrowth was d...
متن کاملRole of the endothelial lining in recurrences after coil embolization: prevention of recanalization by endothelial denudation.
BACKGROUND AND PURPOSE Endovascular treatment can improve the outcome of patients treated for ruptured intracranial aneurysms as compared with surgical clipping, but angiographic recurrences are frequent. Endothelial denudation before coil embolization may prevent recanalization and improve results of endovascular treatment. METHODS We compared angiographic and pathological results 3 months a...
متن کاملRegeneration of endothelial cells after balloon denudation of the rabbit carotid artery and changes in responsiveness.
The present experiments were carried out to determine the regrowth of endothelial cells (EC) after balloon denudation of the rabbit carotid artery and the changes in responsiveness of the artery with regenerated EC. Scanning electron microscopic findings revealed that 28.8% of the luminal surface was covered with regenerated EC at week 1. The regrowth of EC proceeded progressively, and a full l...
متن کاملUp-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1.
Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical denudation. Two VEGF tyrosine kinase receptors have been reported-fms-like-tyrosine kinase-1 (Flt-1) and kinase domain region (KDR). Little is known about the regulation of the expression of these receptors after vascular injury. Herein, we have an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34408-7